Nattokinase works by directly breaking down fibrin, the protein that forms blood clots, and by activating the body’s own clot-dissolving system, boosting tissue plasminogen activator (t-PA) and inhibiting its inhibitor (PAI-1) to enhance fibrinolysis. It also helps lower blood pressure by inhibiting the Angiotensin-Converting Enzyme (ACE), reduces inflammation, and improves overall circulation, supporting cardiovascular health. It also helps lower blood pressure by inhibiting the Angiotensin-Converting Enzyme (ACE), reduces inflammation, and improves overall circulation, supporting cardiovascular health.